Who Benefits From PGS?
Journal: Austin Journal of Invitro Fertilization (Vol.3, No. 1)Publication Date: 2016-02-01
Authors : Brian Dale; Yves Menezo; Kay Elder;
Page : 1-3
Keywords : Blastocyst; PGS; Trophectoderm biopsy; Mosaicism; Epigenetics; Defective signalling;
Abstract
Whilst new generation sequencing techniques of blastocyst biopsies give rapid response times and are more accurate, we question whether counting chromosomes can lead to an improvement in pregnancy rates and if the cost of trophectoderm biopsy outweighs the benefit in PGS. NGS does not define embryo viability or health, as it does not guarantee that genes are free from DNA breaks/errors, or that they will be expressed/transcribed correctly at the appropriate time in preimplantation development. In addition, PGS cannot detect embryos whose health has been jeopardized by metabolic malfunctions due to epigenetic effects resulting from inherent gamete physiology or sub-optimal in vitro culture and handling.
Other Latest Articles
- Isolation, Culture and Characterization of Human Endometrial Mesenchymal Stem/ Stromal Cells (EnMSCs): A Mini Review
- GnRH Agonist Addition to Routine Luteal Phase Support in Assisted Reproductive Technology
- The Insight into Developmental Capacity of Mammalian Cocs and Cumulus-Granulosa Cells-Recent Studies and Perspectives
- Consider Anti-Ovarian Antibody Testing for ART: a Parameter to Improve the Success Rate of Your Clinic!
- Interpretation: Real Time Assessment on Immotile but Viable Spermatozoa for Intracytoplasmic Sperm Injection (Icsi): an Embryologists Outlook
Last modified: 2017-03-30 19:30:45