Novel Autoantibody and Autoantigen in Sjögren’s Syndrome

Over the past more than 30 years since the identification of the now classic anti-SS-A/Ro and anti-SS-B/La autoantibodies in Sjögren's syndrome, there have been a few new and interesting autoantibodies including antifodrin, anti-M3 muscarinic receptor, and other autoantibodies reported to be closely linked to this disease. We have recently identified a novel autoantibody predominantly recognized in Sjögren's syndrome specifically reacting with NA14 (nuclear autoantigen 14 kDa)/SSNA1 (Sjögren Syndrome Nuclear Autoantigen 1). This review describes the current data available for anti-NA-14 antibody in their usefulness of diagnosis and the nature of the autoantibody production in Sjögren's syndrome.