P53 TRANSCRIPTION FACTOR AND DIABETES: IS THERE ANY LINK?
Journal: Journal of Advances in Biology (Vol.9, No. 2)Publication Date: 2016-05-14
Authors : Imtiyaz Murtaza;
Page : 1825-1833
Keywords : P53; Diabetes; Metabolic disorders; Dyslipidemia; theraupetic target;
Abstract
Diabetes, a metabolic disorder is alarmingly increasing across the globe and currently ample of research is being carried out to treat hyperglycaemia and its secondary complications in diabetic patients. Despite extensive research, specific causes of this metabolic disorder are still not well understood at molecular level. As p53 a tumor suppressor gene has mostly been associated with cancer, however, the most recent research studies sheds light on vital role of p53 signalling in diabetes development. In this review we underline the role of altered p53 protein expression in diabetes and its associated metabolic disorders including hypertension and dyslipidemia. We try to throw some light on latest studies that
suggest how p53 signalling may act as a new potential therapeutic target for diabetes and its related metabolic disorders.
Other Latest Articles
- Chromium combination tannage of rural and minimal tanned crusts
- STOMACH CONTENT ANALYSIS OF SOME SELECTED FISH SPECIES FROM GILIMA RIVER, TAURA LOCAL GOVERNMENT, JIGAWA STATE, NIGERIA
- A Comparative Study on Productivity of Salmon Aquaculture in Conventional and PLC-equipped Ponds
- DYNAMICS OF POLYSTYRENE MICROSPHERE LINKING TO λ-PHAGE DNA MOLECULE IN OPTICAL TWEEZERS USING PULSED GAUSSIAN LASER BEAM
- GENETIC DIVERSITY OF CASSAVA (Manihot esculenta Crantz), (EUPHORBIACEAE) GROWN IN THREE AGROCLIMATIC ZONES OF CENTRAL AFRICAN REPUBLIC
Last modified: 2017-04-07 15:25:19