EFFECTIVENESS OF CEFTRIAXONE IN THE TREATMENT OF POST SURGICAL INFECTIONS: ALONE AND IN COMBINATION WITH ASCORBIC ACID

Post surgical infections (PSI) are among the most common hospital acquired infections comprising 14-16 percent of inpatient infections. PSI is a dangerous condition , a heavy burden on the patient and social health system. PSI risk factors are diabetes, malnutrition, smoking and obesity. The aim of the study was to observe the effectiveness of ceftriaxone in the treatment of post surgical infections alone and in combination with antioxidant Ascorbic acid. A retrospective study was conducted on surgically operated patients in the region of Lahore and Sialkot,100 patients were included in study through random sampling technique. Results showed that some patients were taking prophylactic treatment with ceftriaxone and with any other antibiotics, due to lack of sterility factor, inappropriate ventilation and poor patient compliance leads to post surgical infections. Private sector utilized preventive strategy to maintain the sterile conditions in operating room while in public sector preventive strategy not applied. Mostly post surgical infections occur in patients within 7 days of surgery. Staphylococcus aureus was the microorganism most commonly cultured from PSI. The treatment given to patients for PSI include ceftriaxone in combination with NSAIDS, antioxidants and other antibiotics. In patients treating with ceftriaxone in combination with Ascorbic acid, the healing of infection was so rapid as compared to other combinations of ceftriaxone. It was also studied that the cost of treatment also reduced with the use of combination (Ceftriaxone+ Ascorbic acid). Key words: Post surgical infections (PSI), antioxidant, ceftriaxone, Ascorbic acid, Staphylococcus aureus