In vivo and in vitroevaluation of the Acrocomia aculeatapulp oil - lipid profile and oxidative stress

Acrocomia aculeate is a plant species with high levels of antioxidant compounds, rich in carotenoids with high bioavailability and monounsaturated fatty acids. This study was designed to investigate the biological effect of Acrocomia aculeate pulp oil (AaPO) on body weight, epididymal adipose tissue mass , liver weight and blood analyt es of high fat -Diet induced obes eC57BL/6j mice .In addition, the antioxidant properties of AaPO were evaluated against the iron sulfate (FeSO4) induced oxidative damage to rat brain synaptosomes. Obese mice receiving oral gavage with AaPO showed a significant decrease in body weight, adipose tissue weight plasma triacylglycerol and aspartate aminotransferase Histological analysis showed that AaPO attenuate highat - diet - induced liver injury decreasing hepatic steato sis and adipocyte hyperplasia. In addition, the in vitro assays showed that AaPOprevented the FeSO 4 - induced oxidative damage in synaptosom al fractions . Results from this study suggest that AaPO can reduce body weight, plasma triacylglycerol, adipose tissue and oxidative stress .