ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE POLYMORPHISM. PART 1. POLYMORPHIC G894T (GLU298ASP, RS1799983) VARIANT

Objective. To analyze our experience and literature sources about endothelial nitric monoxide synthase gene G894T polymorphisms and the distribution of allele and genotype frequencies. Results. The physiological and pathogenic value of polymorphism of endothelial nitric oxide synthase and the role in aerobic processes are being discussed. Conclusions. Polymorphic G894T (Glu298Asp, rs1799983) variant is associated with the development of a number of pathologies, which necessitates the study of the distribution of allele and genotype frequencies in population of the Republic of Belarus in order to make a preventive diagnosis of diseases. Molecular genetic studies aimed at studying peculiarities of the given endothelial nitric oxide synthase gene polymorphism are important to understand oxygen-dependent processes in the organism.