Simultaneous increased Inteleukine-6 and decreased glucose concentration in response to a single bout cycling exercise

Pro-inflammatory cytokine interleukin-6 (IL-6) is known to play important role in glucose homeostasis. To investigate serum IL-6 response to acute exercise and to determine the relationship between Changes in its levels with changes in glucose concentration in response to exercise. Venous blood samples were obtained before and after a single bout incremental cycling test in order to measuring serum IL-6 and glucose concentration in eighteen none-trained adult overweight or obese men (26 ≤ BMI ≤ 33 kg/m2, 38 ± 6 years). Statistic analysis was done with SPSS 15.0 for Windows using by paired samples T-test and Pearson methods. Cycling exercise test resulted in significant increase in serum IL-6 (p = 0.021) and significant decrease in glucose concentration (p = 0.033). In response to exercise test, Changes in serum IL-6 was negatively correlated with change in glucose concentration (p = 000, r = -0.74). These finding suggest the anti-inflammatory effect of single bout exercise on glucose homeostasis.