ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF CEFDINIR USING SOLID DISPERSIONS

The purpose of this study is to enhance solubility and dissolution rate of poorly water soluble drug. Several techniques such as micronisation, cyclodextrin-complexation, use of surfactants, solubilizers and super disintegrants, solid dispersion in water soluble and water dispersible carriers, microemulsions and self emulsifying micro and nano disperse systems have been used to enhance the solubility and dissolution rate of poorly water soluble drugs. Among the various approaches solid dispersion technique is most widely used. Cefdinir is a drug of choice for solubility and dissolution enhancement. Solid dispersions were prepared by solvent evaporation method and melt fusion method using polyethylene glycol 3350 and PVP-K30 as hydrophilic carriers. The prepared solid dispersions were evaluated in terms of drug content, % yield and in-vitro dissolution study. In-vitro release profiles of all dispersions were comparitively evaluated and also studied against pure cefdinir. The results obtained showed that the rate of dissolution of cefdinir was considerably improved when formulated in solid dispersions as compare to pure drug. Key Words: Poorly water drug, Solvent evaporation, In-vitro dissolution study, Cefdinir.