CLINICAL PROFILE OF PATIENTS WITH THROMBOCYTOPENIA AT TERTIARY CARE HOSPITAL

OBJECTIVE: To determine the clinical profile of patient with thrombocytopenia at tertiary care hospital. PATIENTS AND METHODS: This descriptive case series study for one year was conducted at tertiary care hospital Hyderabad on the patients who had clinical manifestation due to thrombocytopenia. The inclusion criteria of the study were patients, of ≥12 years of age, either gender, had thrombocytopenia counts less than 1, 50,000/µl with or without clinical manifestations. The investigations relevant to detect etiology were advised while the severity of thrombocytopenia was categorized as mild, moderate and severe. The data was collected on pre-designed proforma and analyzed in SPSS 16. The frequency and percentage was calculated while mean ± SD was computed for numerical variables. RESULTS: During one year study period total one hundred patients of thrombocytopenia were recruited and studied. Majority of the patients belonged to rural population (78%). The mean ±SD for age and platelet count was 38.98 ±8.95 years and 1, 10500 ± 4500 / µl respectively while the mortality was detected as 11%. The male population was predominant 53%, the fever is the most common clinical presentation observed in all participant while the other common symptoms observed were gum bleeding (19%), hematuria (19%), menorrhagia (15%) and melena (14%). The common etiological factors detected as Plasmodium vivax (21%), Plasmodium falciparum (16%), dengue (19%), tuberculosis (13%) and viremia (13%) while the bleeding time was detected as prolonged in 37% respectively. CONCLUSION: The thrombocytopenia is a common and life threatening complication of febrile illness especially of infectious origin. Keywords: Platelet, Thrombocytopenia, Megakaryocytes