Acute response of serum leptin to short single bout exercise in patients with moderate asthma

Recently, it has been hypothesized that leptin levels is increased during allergic reactions in the airway and may be a role in asthma prevalence, but the mechanisms underlying this response are a matter of some debate. The objective of this study was to evaluate the effect a stepwise incremental bicycle test on a bicycle erogometer on serum leptin in asthma patients and to determine its changes role in response to exercise on respiratory functional in these patients. For this purpose, twenty middle-aged males with moderate asthma participated in this study by accessible sampling. Pre and post training blood samples and respiratory functional test were performed in order to measuring serum leptin and spirometry parameters in all patients. Pre- to post training changes were determined by two-tailed t tests. The bivariate associations between changes in leptin concentrations with respiratory function were examined with the Pearson rank correlation analysis. No significant differences were found in serum leptin by cycling exercise with compared to baseline (p ≥ 0.05). Compared to pre-exercise, the spirometric marker levels as FEV1 and FVC increased significantly after cycling exercise (p ˂ 0.05). We found no evidence that changes in serum leptin were associated with changes in each spirometry markers in response to exercise test (p ≥ 0.05). Based these data, we can say, exercise for a session can not affect serum leptin in asthma patients and the change in serum leptin by short-time exercise is not associated with respiratory functional in these patents.