Tubulointerstitial nephritis with uveitis syndrome A CASE REPORT

Abstract : Tubulointerstitial nephritis and uveitis (TINU) syndrome was first described in 1975 by Dobrin. It is usually seen in children and young adults females are affected more often than males. The nephritis usually precedes the uveitis, although simultaneous onset of both organs has been described. Patients usually present with systemic signs and symptoms including fatigue, malaise, anorexia, abdominal pain, fever and anaemia. The acute renal dysfunction is due to nephritis and typically resolves spontaneously or responds favourably to systemic steroid therapy. However, cases of nephrotic syndrome, relapsing nephritis and development of chronic renal failure, despite the use of systemic steroids and other immunosuppressants (chlorambucil and cyclophosphamide), have also been reported. A few patients eventually require dialysis K