Incidental renal cell carcinoma with endometrial adenocarcinoma: A rare case report

Incidental detection of two primaries call for oncosurgeon's own judgment to decide the best therapeutic approach as no guidelines exist for the rarity of condition. This is the rare case of incidental renal cell carcinoma in a patient of endometrial carcinoma. Renal cell carcinoma was detected on preoperative MRI in a patient who presented as postmenopausal bleeding and histology proven endometrial carcinoma. Final histology confirmed dual primaries with uterine primary being endometrioid adenocarcinoma, whereas renal primary was clear cell carcinoma stage II. Estrogen receptors (ER) have been identified in Hamster and Mouse kidneys as well as in renal cell carcinoma tissues. High plasma estrogen found in some patients of synchronous renal and endometrial cancer may partly explain the association of these two primaries, though not in all cases. Increased serum leptin levels and a common low penetrance susceptibility gene have been reported in both these cancers.