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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION METAL COMPLEXES OF 2- AMINO ACETATE – 6 – BROMO BENZOTHIAZOLE

Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.04, No. 04)

Publication Date:

Authors : ; ; ;

Page : 965-970

Keywords : amino acetate benzothiazole; Transition metal complexes; Antibacterial activity;

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Abstract

Five new metal complexes of the ligand 2-amino acetate - 6 - bromo benzothiazole with some metal ions Ni(II), Cu(II), Sn(II) Zn(II), and Cd(II) were synthesized and evaluated for their anti-bacterial activity. The prepared complexes were characterized by 1H, Fourier transform infrared spectra, UV-Visible spectroscopy, magnetic moment, and conductivity measurement. The spectral study showed that all the complexes obtained as monomeric structures and central metal moieties are four–coordinated, with tetrahedral geometry, except for the copper complex, which had square planar geometry. All the complexes showed moderate activity against Gram-positive and Gram-negative pathogenic bacteria using disc diffusion method. Keywords: amino acetate benzothiazole, Transition metal complexes, Antibacterial activity

Last modified: 2017-04-30 15:45:50