Optimization of physiochemical parameters for the production of withaferin A employing cell suspension culture of Withania somnifera : A review

Withania somnifera (Ashwagandha ) is a plant used in medicine from the time of presence by ayurveda, the ancient system of Indian medicine and in plant biotechnology. The dried roots and leaves of the plant are used in the treatment of various nervous and sexual disorders. Medicinal properties of plant have been attributed to the presence of a group of steroidal lactones which are known as withanolides which are present in roots and leaves. Withaferin A is a steroidal lactone being derived from Withania somnifera. It is used in ayurvedic medicine. It has a wide range of activities which comes under pharmacy ,cardio protection, the anti-inflammatory agent , an immuno modulatory, an anti-angiogenesis, anti-metastasis and anti-carcinogenic property. This review article is focusing on the methodology to achieve the maximum production of withaferin A employing cell suspension culture of Withania somnifera. As withaferin A low concentration was found to be a limiting factor in previous reports on Withania somnifera . This article will encompass the parameters which are responsible for optimum production of withaferin A employing cell suspension culture of Withania somnifera.