Method development and validation of zolmitriptan in bulk and tablet dosage form by RP-HPLC
Journal: International journal of Pharmaceuticals and Health care research (Vol.01, No. 4)Publication Date: 2013-12-30
Authors : Subhashini B Ananda Thangadurai S Jambulingam M Kamalakannan D Farheen Kausar M;
Page : 156-160
Keywords : Zolmitriptan; RP-HPLC; ICH.;
Abstract
A simple, precise, accurate, reproducible and robust HPLC method was developed for the estimation of Zolmitriptan in tablet dosage form. The method was validated as per ICH guidelines. Analysis of the drug was performed on Waters X terra C18 column (250 mm x 4.6 mm x 5 ?), consisting of mobile phase, employing phosphate buffer and methanol (80:20 V/V) as mobile phase at a flow rate of 1 ml/min, The retention time of drug was found to be 4.432 min. The estimation of drug was carried out at 225 nm using UV-Visible detector. The method produced good linear responses in the concentration range of 12.5 to 75 ?g/ml. The % RSD for inter-day and intraday precision was found to be 0.771 and 0.7750 respectively. The proposed method was found to be applicable for determination of the drug in tablet dosage form.
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