MODULATION OF CHOLINOLYTIC EFFECT OF SODIUM OXYBATE BY HEPARINE

In the experiments on cats with cholinoceptive structures of superior cervical ganglion (SCG) as a test object, it was shown that intra-arterial injection in lingual artery of 100 mg/kg of sodium oxybate blocks interneuronic excitation transfer at the level of pre- and postsynaptic structures. Various doses of heparine do not influence the process of interneuronic transfer; however, heparine reduces cholinolytic properties of gamma hydroxy-butanoic acid significantly. The authors suggest that heparine makes a complex compound with sodium oxybate. Moreover, heparine introduction is associated with sensibilization of ganglion cholinergic receptors.