Primary Intracranial Leiomyosarcoma of the Cavernous Sinus: Case Report

Primary intracranial leiomyosarcoma is extremely rare. Herein, we describe a case of primary intracranial leiomyosarcoma of the cavernous sinus in which stereotaxic radiotherapy was effective. A 75-year-old woman presented with acute-onset left eye pain and ptosis of the left eyelid. MR images revealed a hypointense homogeneous lesion in the left cavernous sinus, which was subsequently diagnosed via biopsy as leiomyosarcoma. Stereotaxic radiation with a fractionated Cyberknife radiosurgery was conducted. Following the treatment, a marked reduction in the tumor size was observed. Thereafter, the patient had local recurrence and died after a course of 44 months. Primary intracranial leiomyosarcoma is extremely rare and the prognosis is relatively poor. Cyberknife radiosurgery may be a useful treatment for unresectable primary intracranial leiomyosarcoma.