A Case of Progressive Transformation of Germinal Centers in an HIV-Infected Patient

Progressive Transformation of Germinal Centers (PTGC) is an uncommon condition, characterized by a reactive lymph node hyperplasia with enlarged follicles and expansion of mantle zone lymphocytes into adjacent germinal centers. The disorder presents with persistent asymptomatic lymphadenopathy, generally affecting cervical, inguinal and axillary nodes, and sometimes is associated with Hodgkin's lymphoma and other diseases. Prognosis is generally good, and treatment is conservative in most cases. We report a patient with HIVinfection who presented with persistent impressive lymphadenopathies due to PTGC.