Treating Mitochondrial Myopathy: Can we Boost Oxidative Phosphorylation Activities by Enhancing Mitochondrial Biogenesis?

In clinical practice today, only symptomatic therapeutic approaches are available to patients with mitochondrial myopathies. A possible innovative strategy to ameliorate oxidative phosphorylation deficiency would be to increase the mitochondrial load of the patient's muscle tissue. Some of the most promising stimulators of mitochondrial biogenesis: resveratrol, quercitin, catechins and fibrates, are evaluated in this review. Results so far are promising, but there is need to determine if sufficient mitochondrial proliferation can be achieved to normalize OXPHOS function in patients with mitochondrial myopathy.