Central Odontogenic Fibroma, its Treatment and its Recurrence: A Systematic Review

Introduction: The central odontogenic fibroma (COF) is an extremely rare benign neoplasm of intraosseous or central presentation, being itself only 0.1% of all odontogenic tumors. The purpose of this systematic review is to provide an overview of the treatment of the central odontogenic fibroma and its recurrence. Methods: Following PRISMA guideline, a systematic review was carried out. Results: The initial search retrieved 51763 articles identified through database searching, and 41 articles identified through manual search. After examination of the title and the abstract, 83 articles were retrieved for further examination. Sixty-two articles were included, thus obtaining a total of 104 patients.The recurrence of the 84 patients was 4.76%. Discussion: The recurrence reports vary in the literature. The most recent review by Garcia-Cano E, et al., showed no recurrence whatsoever; Ramer and colleagues reported only 5 cases of recurrence. However, only 39 cases out of 68 were followed up. In this systematic review out of 84 patients, 4 (4.7%) presented recurrence. From these, 3 cases were treated by enucleation and one by curettage. Conclusion: The recurrence rate in these tumors is very low and mainly related to an incomplete resection. Therefore, conservative surgery must be done as a first-line treatment.