Aryl α, β-Unsaturated Ketones as Efficient Precursor for Synthesis of Unsaturated 1,3-oxazine-2-amines under Solvent-free Conditions
Journal: International Journal of Scientific Research in Environmental Sciences (Vol.1, No. 12)Publication Date: 2012-12-01
Authors : Ganesamoorthy Thirunarayanan;
Page : 580-596
Keywords : Unsaturated 1; 3-oxazine-2-amines; α; β-Unsaturated ketones; KF/Al2O3; Environmentally benign reaction; IR and NMR spectra;
Abstract
Abstract. Present study describes the efficient synthesis of some unsaturated 1,3-oxazine-2-amines including thirteen 4-(6-methoxy-2-naphthyl)-5,6-dihydro-6(substituted phenyl)-4H-1,3-oxazine-2-amines by KF/Al2O3 catalysed solvent-free cyclization of enones with urea under microwave irradiation. The yields of the synthesized oxazines are more than 85%. The catalytic activity of this catalyst was studied by increasing the catalyst quantity from 0.05 to 0.25g in the step-wise cyclization of chalcone and urea. The optimum quantity of the catalyst for this cyclization will be found to be 0.2 g. The effect of solvent on the cyclization reaction was studied with conventional heating method and microwave irradiation technique. Comparatively, the microwave assisted solvent-free method gave more yields of the product. In this study, the effect of substituents also studied. The electron donating substituted chalcones gave more yield than electron-withdrawing substituted chalcones. This synthetic methodoly offers easy work-up procedure, non-hazardousness, shorter reaction time, environmentally benign reaction and better yield. The physical constants, analytical and spectroscopic data are supported for establishment of their structure.
Other Latest Articles
- The Investigation of the Impact of Lucobit Polymer on Bitumen Performance
- Evaluating the Prioritization of Transportation Network Links under the Flood Damage: by Vulnerability Value and Accessibility Indexs
- Stabilization of Clayey Soil with Lime and Waste Stone Powder
- A Survey of the Effects of Social and Psychological Indices on the Economic Capability of Rural Women (Case Study: Hamadan City)
- 2D Electrical Resistivity Imaging for the Investigation of the Subsurface Structures at the Proposed Site for Kauridan Estate at Ibagwa ? Nike, Southeastern Nigeria
Last modified: 2014-01-16 00:19:20