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Stereoselective Synthesis of C1 -C6 and C7 -C22 Fragments of (-) Callystatin A

Journal: International Journal of Bioorganic Chemistry & Molecular Biology (IJBCMB) (Vol.03, No. 01)

Publication Date:

Authors : ; ; ;

Page : 1-11

Keywords : (–)-Callystatin A; Desymmetrization; Horner-Wadsworth-Emmons reaction;

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Abstract

The stereoselective synthesis of the two major fragments (C1 -C6 and C7 -C22) of cytotoxic polyketide marine natural product (-) callystatin A, has been achieved with Sharpless epoxidation, desymmetrization strategy, Horner-Wadsworth-Emmons reaction and witting olefination.

Last modified: 2017-05-31 13:48:52