Stereoselective Synthesis of C1 -C6 and C7 -C22 Fragments of (-) Callystatin A
Journal: International Journal of Bioorganic Chemistry & Molecular Biology (IJBCMB) (Vol.03, No. 01)Publication Date: 2015-10-21
Authors : Kurra Y; Sabitha G; J.S. Yadav;
Page : 1-11
Keywords : (β)-Callystatin A; Desymmetrization; Horner-Wadsworth-Emmons reaction;
Abstract
The stereoselective synthesis of the two major fragments (C1 -C6 and C7 -C22) of cytotoxic polyketide marine natural product (-) callystatin A, has been achieved with Sharpless epoxidation, desymmetrization strategy, Horner-Wadsworth-Emmons reaction and witting olefination.
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