Caveolin-1 Polymorphisms and Cancer risk in Asian: A Meta - Analysis

Cancer is the leading cause of death in the world. Genetic factors can influence the susceptibility and pathophysiology of cancer. Single nucleotide polymorphisms are the most common genetic variation and have become a focus in cancer research. In recent years, considerable research has indicated the link between CAV-1 polymorphism and cancer susceptibility. However, individual studies are inconsistent. We conducted a meta-analysis to eliminate this inconsistency. We performed a systematic computerized search of PubMed, ISI Web of Knowledge, and Chinese National Knowledge Infrastructure Data using the following keywords: “CAV-1,” “Caveolin-1,” “polymorphism,” “variant,” and “cancer”. Pooled odds ratios with 95% confidence intervals were used to evaluate the strength of the association between CAV-1 polymorphism and cancer risk. Publication bias was estimated using Begg's funnel plots and Egger's regression test. The study showed that rs3807987 A>G polymorphism increased the risk of cancer in all five comparison models, and rs7804372 A>T polymorphism decreased the risk of cancer. However, no significant association was found in rs1997623, rs12672038, rs3757733, and rs3807992 polymorphisms and cancer. Egger's test results did not indicate any evidence of publication bias in this study. In conclusion, our meta-analysis showed that CAV-1 rs3807987 A>G polymorphism increased the risk of cancer and rs7804372 A>T polymorphism decreased the risk of cancer. Further studies that include different ethnicities and with a large population size should be conducted to reach a comprehensive conclusion.