Development and in vitro Evaluation of Floating Microparticles of Cimetidine

Microspheres of Cimetidine by emulsion solvent diffusion technique were prepared for sustained delivery by using polymers like Ethyl cellulose and Carbopol 934in order to extend the drug release for about 12 h in the upper GIT, which may result in enhanced absorption and there by improved bioavailability. The particle size was determined by optical micrometer and average particle size was found to be in range of89.5± 2.63 to 124.33± 2.14. Formulation F2 containing Ethyl cellulose and Carbopol 934 polymer blend showed the best floating ability (97.5%) as compared with other formulations. From Scanning Electron Microscopy (SEM) it was observed that, Microparticles were found to be spherical in shape with smooth surface texture with a hollow space within. Among all formulations, F2 showed appropriate balance between buoyancy and drug release rate of 88.65% in 12 h, which was considered as the best formulation.