Biological Role of Leptin in Management of Obesity

Nowadays obesity is a major health problem all over the worlds especially in developed and developing countries. A person with a BMI equal to or more than 25 is considered overweight. Excess body weight is a result of an imbalance between energy intake and energy expenditure. Obesity is responsible for a number of health complications like diabetic and cardiovascular. Drugs available in market posses a number of adverse effects. Leptin is adipose derived cytokine which is essential for regulation of body weight and energy balance. Leptin regulate lipid profile and glucose metabolism, neuroendocrine functions. Leptin exerts immediate effects by acting on the brain to regulate appetite. Leptin is the first identified adipose-tissue-derived cytokine, which exerts profound functions in the regulation of food intake, energy expenditure, glucose metabolism, reproduction and immune response.