FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF TENOFOVIR DISOPROXIL FUMARATE (TDF) IMMEDIATE RELEASE TABLETS

In the present work, an attempt has been made to develop immediate release tablets of Tenofovir Disoproxil Fumarate (TDF). In the present work Sodium starch glycollate and Cross carmellose sodium were employed as super disintegrating agents for the selected drug molecule.. All the formulations were prepared by wet granulation method. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F9 formulation showed maximum % drug release i.e., 99.3 % in 25 min hence it is considered as optimized formulation. Keywords: Tenofovir Disoproxil Fumarate (TDF), Immediate release tablets, Sodium starch glycollate , and Cross carmellose sodium.