PAMAM DENDRIMERS AS DRUG DELIVERY CARRIERS, BENEFITS AGAINST RISKS

Objectives: The aim of this review is to provide brief description of synthesis, structure, properties and uses of PAMAM dendrimers with providing some detailed examples of using PAMAM as promising drug delivery carrier. Findings: Dendrimers as novel polymeric symmetric materials with three dimensional architecture represent a growing substrate for drug delivery. They possess different structural and physical properties that enable them to conjugate with different drugs to form organ-targeting drug delivery systems. PAMAM (Polyamidoamine) is the most studied and commercially available type of dendrimers. PAMAM has been reported in different research papers to have many pharmaceutical benefits such as solubility enhancement, permeability enhancement, gene transfer, and organ-targeting drug delivery carrier. PAMAM has some concerns about its cellular toxicity, but many studies suggested its biocompatibility and non-toxicity on biological tissues. Summary: PAMAM dendrimers represent excellent promising drug delivery carrier systems with many benefits and substantial risks which require further studying and challenging Key words: Ciliotoxicity- Dendrimers- PAMAM- Targeted Drug Delivery.