Design and Characterization of Floating Tablet of Rabeprazole
Journal: Current Research in Pharmaceutical Sciences (Vol.5, No. 3)Publication Date: 2015-09-30
Authors : Manoj Kumar Goyal; Ashutosh Dubey; Hariom Tyagi;
Page : 106-111
Keywords : ;
Abstract
The present study was aimed at preparing sustained floating drug delivery system of Rabeprazole to increase its gastric residence time and bioavailability after oral administration. Total ten formulations were formulated by direct compression technique using HPMC K15M, HPMC K100M and ethyl cellulose (floating agent) as polymers along with sodium bicarbonate as gas generating agent. The formulations were evaluated for their physicochemical properties, buoyancy lag time, total floating time, swelling index and invitro drug release. All ten formulations possessed good floating properties with total floating time >12 hrs.
Other Latest Articles
- Formulation and Evaluation of Floating Tablet of Cefadroxil
- Polysaccharides for Bacterially Triggered System in Colon Targeting
- Formulation Design, Optimization and Evaluation of Carvedilol Phosphate Gastro Retentive Floating Tablets
- Scope and Job Opportunities in Pharmacy: An Overview
- A Review on Outbreak of Zika Virus
Last modified: 2017-06-06 03:13:04