Design and Characterization of Floating Tablet of Rabeprazole

The present study was aimed at preparing sustained floating drug delivery system of Rabeprazole to increase its gastric residence time and bioavailability after oral administration. Total ten formulations were formulated by direct compression technique using HPMC K15M, HPMC K100M and ethyl cellulose (floating agent) as polymers along with sodium bicarbonate as gas generating agent. The formulations were evaluated for their physicochemical properties, buoyancy lag time, total floating time, swelling index and invitro drug release. All ten formulations possessed good floating properties with total floating time >12 hrs.