Floating Tablets: A Single Unit Approach to Increase the Gastroretention of Cefpodoxime Proxetil

The main objective of the present study is to develop a single unit gastric floating drug delivery system (GFDDS) of Cefpodoxime Proxet.Tablets were prepared using various proportions of polymers such as HPMCK4M and Eudragit RS 100. Direct compression method was used for the preparation of tablets. Five different formulations were developed. Tablets were evaluated for physical characterization viz. weight variation, thickness, hardness, friability, drug content, swelling index, buoyancy determination, and in vitro drug release study. All parameters complied with IP limits. Formulation with both the polymers (F5) showed sustained release. Formulations with hydrophilic polymer (F1, F2) showed high release of drug when compared to formulations with hydrophobic polymers (F3, F4). Polymer HPMCK4M and the combination of Eudragit RS100 were found to have optimum floating characters for a longer period. It may be concluded from whole study that the combinations of hydrophilic polymers with hydrophobic polymers are suitable to optimize sustained release formulation of Cefpodoxime Proxetil.