Anticonvulsant and CNS Depressant Activity of Methanolic Extracts of Whole Plant of Sida acuta and Sida rhombifolia in Mice

O investigate the anticonvulsant and CNS depressant activity of methanolic extracts of whole plant of Sida acuta and Sida rhombifolia in mice. The methanolic extract of whole plant of Sida acuta (MESA) and Sida rhombifolia (MESR) (100, 200 and 400 mg/kg, p.o.) was studied for its anticonvulsant effect on maximal electroshock (MES) induced seizures and Pentylenetetrazole (PTZ) induced seizures and CNS depressant activity at the same dose level using traction test, rota rod and locomoter activity in mice. MESA and MESR at dose 100, 200 and 400 mg/kg significantly reduced the duration of the seizures as compared to control group. In CNS depressant activity and the mean time duration on rotating rod was significantly decreased (P<0.0001) and decline in motor co-ordination.