Formulation and Evaluation of Salicylic Acid and Urea Gel for Treatment of Psoriasis

Gel containing salicylic acid and urea with five different proportions of carbopol polymer were prepared. These formulations were studied for pH, drug content, viscosity, spreadability, extrudability, skin irritation studies, in-vitro studies and stability studies. The formulated gel F3 shows pH 7.0, drug content 85 % and 89 % of salicylic acid and urea respectively, viscosity 10000 cps, spreadability24.6 gm.cm/sec, extrudability 75.1 %, no skin irritation, in-vitro drug release of salicylic acid and urea were found to be 71 % and 81 % respectively. After stability studies of formulation F3, all the above datas comes in acceptable range.