QSAR on Heteroaryl-Phenyl-Substituted Pyrazole Derivatives as Selective and Potent Canine COX-2 Inhibitors

A series of heteroaryl-phenyl-substituted pyrazole derivatives was subjected to QSAR analysis and the equations generated thereof showed good correlation between COX-2 inhibitory activity and physico-chemical as well as steric properties of the derivatives. One of the significant equations generated has a r value of 0.859 and cross validated r2 (q2) value of 0.534. The contributing parameters include Connolly Accessible Area (CAA), Principal Moment of Inertia at z-axis (PMZ) and Partition Coefficient (PC). Keywords: COX-2, QSAR, steric parameters, physicochemical properties, regression, statistical validation