Oral dissolving films of Celecoxib inclusion complexes using Musa paradisiaca as super disintegrant in treatment of Psoriatic arthritis
Journal: Journal of Pharmacy Research (Vol.11, No. 5)Publication Date: 2017-05-08
Authors : Padmini Iriventi; N. Vishal Gupta;
Page : 517-521
Keywords : Celecoxib; Psoriatic arthritis; Musa paradisiaca; Oral dissolving film.;
Abstract
Celecoxib is a poorly water soluble drug which is a selective COX-2 inhibitor used in treating Psoriatic arthritis. It shows poor dissolution and flow properties. So physical mixures of the drug using solubilizers like β CD were prepared in order to enhance its solubility and dissolution rate. Super disintegrant plays a vital role in increasing drug release. Musa paradisiaca, a natural excepient is used in this study as a super disintegrant. The aim of present study was to formulate oral dissolving films of Celecoxib using solubilizer and evaluate them for in vitro disintegration and dissolution rates. It was found that β CD had shown good impact on increasing solubility and dissolution rate. Drug excepient compatibility was studied by FTIR studies.
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