CYTOKINE PROFILE OF PERIPHERAL BLOOD AT PATIENTS WITH PERIODONTITIS

Clinical immunoassay of 25 patients with chronic general periodontitis of medium severity and 14 patients with intact parodontium was conducted. The content of pro-inflammatory cytokines TNF-alpha, IL-2, IL-6 and anti-inflammatory cytokine IL-4 was determined in venous blood serum. The firm increase in the level of proinflammatory cytokines TNF-alpha and IL-6 was determined at patients with periodontitis. The content of TNF-alpha and IL-6 increased 3.96 and 1.7 times respectively. The significant variability in volume of material of proinflammatory cytokine IL-2 and anti-inflammatory cytokine IL-4 in peripheral blood at patients with chronic periodontitis was noted. The content of anti-inflammatory cytokine IL-4 decreased 1.4 times, but it was not statistically significant due to significant variability of the obtained results, which allow considering the role of imbalance of cytokine profile in disease pathogenesis.