Cytotoxic Effect Of Verapamil On Human Embryonic Kidney Cell Line
Journal: International Journal of Scientific & Technology Research (Vol.5, No. 12)Publication Date: 2016-12-15
Authors : Jamil L Ahmad; Chukwudi C Okebaram; Abdullahi Samaila;
Page : 83-87
Keywords : Anti-hypertensives; cancer; growth inhibition; proliferative; verapamil;
Abstract
Introduction The link between long term use of verapamil and cancer development has been suggested in literature many years back. However there are numerous controversies surrounding this association with several epidemiological studies in the positive negative and non-association between verapamil and cancer development. Aim To investigate in mechanistic terms the link between chronic use of a calcium channel blocker verapamil and cancer development using human embryonic kidney HEK293 cell line. Method Trypan blue dye exclusion cell counting and 3-26615314 5-Dimethylthiazol-2-yl2661533-2 5-diphenyl-tetrazolium bromide MTT assays were used to determine the proliferative as well as cytotoxic effects of verapamil. Results Verapamil had a growth inhibitory rather than proliferative effect on HEK293 cells and the growth inhibition was found to be significant p0.05. Conclusion The long term use of verapamil is associated with cellular growth inhibition and this possibly explained the rationale behind its use as part of combination chemotherapy for some human cancers.
Other Latest Articles
- Impact Of Heating Temperature On Primary And Secondary Breakup Of Pure Vegetable Oil Spray
- A Research On Fibre Optic Data Transmission
- National Innovation System And Culture A Cross-Country Analysis
- Impact Of Seasonal Malaria Chemoprevention On Morbidity And Mortality Dues To Malaria Among Children Under Five Years In Chad.
- Availability Perception And Constraints Of Final Year Students To The Use Of Computer-Based Information Communication Technologies Cb-Icts.
Last modified: 2017-06-11 22:53:58