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Efforts Towards The Total Synthesis Of Aureobasidin L

Journal: International Journal of Scientific & Technology Research (Vol.6, No. 3)

Publication Date:

Authors : ;

Page : 64-71

Keywords : aureobasidin L; 2S; 3S-Hmp-AbL; solid-phase peptide synthesis.;

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Aureobasidin L AbL 2 was synthesised using a strategy applied for the synthesis of analog 2S3S-Hmp-AbL 1 through a combination of solution- and solid-phase peptide synthesis. It was assumed that the synthesis of the natural AbL 2 will be more straightforward than the synthesis of the analog 2. However some issues were found during the synthesis. Due to these issues a small amount of AbL 2 was obtained. The AbL 2 was characterized by ESI-MS analysis and a comparison of 1H-NMR spectrum between AbL 2 and 2S3S-Hmp-AbL 1.

Last modified: 2017-06-11 22:59:54