Efforts Towards The Total Synthesis Of Aureobasidin L

Aureobasidin L AbL 2 was synthesised using a strategy applied for the synthesis of analog 2S3S-Hmp-AbL 1 through a combination of solution- and solid-phase peptide synthesis. It was assumed that the synthesis of the natural AbL 2 will be more straightforward than the synthesis of the analog 2. However some issues were found during the synthesis. Due to these issues a small amount of AbL 2 was obtained. The AbL 2 was characterized by ESI-MS analysis and a comparison of 1H-NMR spectrum between AbL 2 and 2S3S-Hmp-AbL 1.