Unusual Presentation of CML in Pregnancy

Background: Leukemia during pregnancy is rare, posing a complex series of questions, including appropriate therapy and maternal counseling. Management of chronic myelocytic leukemia (CML) during pregnancy is limited. Case: Our patient presented at 33 weeks of gestation with antepartum haemorrhage due to abruptio placentae. On examination there was massive splenomegaly and peripheral smear showed marked leukocytosis suggestive of CML. She delivered a live, preterm baby weighing 1.54 kg. Post delivery therapy included imatinib mesylate and she responded well to treatment. Conclusions: Definitive treatment of CML should not be delayed due to pregnancy.