Mckittrick-Wheelock Syndrome and Diabetes Insipidus

Secretory villous adenoma is characterized with watery diarrhea, which may lead to dehydration, with resulting volume depletion, electrolyte imbalance, circulatory failure and renal dysfunction. We hereby report a case of villous adenoma associated with severe electrolyte imbalance complicated by diabetes insipidus. Successful management is available by strict preoperative monitoring and surgical resection of the tumor. The pathophysiology of this syndrome and the therapeutic implications are reviewed.