Nephrotic Syndrome as the Initial Presentation of Polycythemia Vera

Polycythemia Vera as an entity of Myleproliferative Neoplasm (MPNs) has infrequent renal involvement which is usually late and rarely recognized. It is characterized clinically by nephrotic range proteinuria and renal insufficiency. The histological pattern of affection is mostly glomerular and is characterized by a combination of mesangial sclerosis, hypercellularity, segmental sclerosis and features of chronic Thrombotic Microangiopathy (TMA). Clinical and histological awareness is needed to establish diagnosis and achieving possible reversibility