Acute Necrotizing Pancreatitis with Gastric Necrosis in a Female with Cerebral Palsy

The coexistence of drug -induced pancreatitis and gastric necrosis is very rare. Many drugs have been associated with pancreatitis and among the antiepileptic drugs; valproic acid has been commonly implicated. Carbamazepine-induced pancreatitis has been rarely reported in the literature because linking this medication to pancreatitis has been difficult given the wide range of more common etiologies. We report an autopsy case of acute pancreatitis with gastric necrosis in a 27-year-old female with cerebral palsy on long term carbamazepine therapy. The causal association of acute pancreatitis and gastric necrosis is discussed based on review of the literature.