Synthesis, chracterisation and antimicrobial activity of 1-[3/-(substituted phenyl)-5/-amino pyrimidine ] -3-(substituted phenyl)-5-(substituted phenyl)-2-pyrazolines as potential antimicrobial agent

2-pyrazoline and pyrimidine derivatives play the vital role in the field of drug discovery. In recent decades a large number of pharmacological studies has been done, but still more research is required in order to exigency of biological compounds with enhanced activity, efforts have been made to accommodate 2-pyrazoline and amino pyrimidine in a single molecular framework. In the present study some novel 2-pyrazoline analogues with amino pyrimidine moiety 4(a-h) have been synthesized by refluxing N-substituted chalcone 2-pyrazoline 3(a-h) with guanidine carbonate and characterized by a combined use of IR, NMR (1H, 13C), Mass spectrometry and elemental analysis. All the compounds were evaluated for their antibacterial activities against Bacillus substilis, Streptococcus aureus: gram positive strain, Pseudomonas aeruginosa, Escherichia coli: gram negative strain and antifungal activities against Aspergillus niger. Among all, 4d and 4e displayed good inhibitory profile against all micro-organisms used for study. All compounds showed relatively good inhibition against Pseudomonas aeruginosa and Streptococcus aureus. All compounds showed poor to moderate activity against Aspergillus niger. Many compounds showed relatively moderate to good activity against all micro-organisms.