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THE FREQUENCY OF METHYLENETETRAHYDROFOLATEREDUCTAS E GENE C677T SINGLE NUCLEOTIDE POLYMORPHIS M IN INDIVIDUALS OF DIFFERENT SEX

Journal: Journal of Clinical and Experimental Medical Research(JC&EMR) (Vol.1, No. 4)

Publication Date:

Authors : ; ; ;

Page : 385-389

Keywords : gene polymorphism; methylenetetrahydrofolate reductase; sex; body mass index;

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Abstract

C677T polymorphism (rs 1801133) of methylenetetrahydrofolatereductase gene (MTHFR) in 124 healthy individuals was determined. It was shown that the ratio of major homozygous allele (C/C), heterozygotes (C/T) and homozygotes for the minor allele (T/T) was 46 %, 48.4 % and 5.6 %. Frequency of individuals-carriers of the minor allele (C/T+T/T) among men was higher than among women (P = 0.061). Female carriers minor allele (C/T+T/T) growth was significantly lower, and BMI was higher compared with women who were homozygous for major allele (C/C) (P < 0.001, P = 0.034 respectively).

Last modified: 2014-01-28 22:32:47