THE FREQUENCY OF METHYLENETETRAHYDROFOLATEREDUCTAS E GENE C677T SINGLE NUCLEOTIDE POLYMORPHIS M IN INDIVIDUALS OF DIFFERENT SEXJournal: Journal of Clinical and Experimental Medical Research(JC&EMR) (Vol.1, No. 4)
Publication Date: 2013-12-15
Authors : Sukhareva V. A. Garbuzova V. Yu. Ataman A. V.;
Page : 385-389
Keywords : gene polymorphism; methylenetetrahydrofolate reductase; sex; body mass index;
C677T polymorphism (rs 1801133) of methylenetetrahydrofolatereductase gene (MTHFR) in 124 healthy individuals was determined. It was shown that the ratio of major homozygous allele (C/C), heterozygotes (C/T) and homozygotes for the minor allele (T/T) was 46 %, 48.4 % and 5.6 %. Frequency of individuals-carriers of the minor allele (C/T+T/T) among men was higher than among women (P = 0.061). Female carriers minor allele (C/T+T/T) growth was significantly lower, and BMI was higher compared with women who were homozygous for major allele (C/C) (P < 0.001, P = 0.034 respectively).
Other Latest Articles
Last modified: 2014-01-28 22:32:47