A Hybrid Peripheral Giant Cell Granuloma-Peripheral Ossifying Fibroma Lesion Presenting as a Solitary Gingival Enlargement

Clinical and radiographic presentations of gingival enlargements often overlap. Definitive diagnosis is made after histological evaluation of excised tissues. Sometimes this is also confusing because it may show features of different clinical entities producing a diagnostic dilemma. Hybrid lesions are lesions which present features from different pathologies. We present a case of hybrid lesion which shows features of peripheral giant cell granuloma (PGCG) and Peripheral ossifying fibroma (POsF) presenting as solitary gingival enlargement involving the maxilla in a 57 year old female patient. The clinical, radiographic and histological features are described in detail. The purpose of this paper is to highlight the importance of thorough evaluation of hybrid lesion to get a proper diagnosis, understand their biologic behaviour and plan treatment to minimise tissue destruction and prevent recurrence. This case also points to the need to reconsider our diagnostic criteria of various enlargements and incorporate hybrid lesions as distinct clinical entity.