UPDATED REVIEW OF GASTRORETENTIVE DRUG DELIVERY SYSTEM

Recent technological and scientific research has been devoted to the development of rate controlled drug delivery systems to overcome physiological adversities such as short gastric residence times and unpredictable gastric emptying times. Differences in gastric physiology such as gastric pH and motility exhibit both intra and inter subject variability demonstrating significant impact on gastric residence time and drug delivery behavior. We have reviewed various gastro retentive approaches designed and developed until now i.e. floating drug dosage systems (FDDS), swelling or expanding systems, mucoadhesive systems, high density system, Raft forming system, magnetic systems. Among these systems, FDDS have been most commonly used. Finally, Evaluation, advantages, disadvantages, future potential and marketed preparation of gastro retentive drug delivery systems were covered.