FORMULATION AND EVALUATION OF ETHOSOMAL GELS OF MANGIFERA INDICA LEAF EXTRACT

Aim: The study was designed to evaluate the ethosomal gel of leaf extract of Mangifera indica, its incorporation in to gel formulations and to characterize the developed ethosomes and gel formulations using various parameters. Methods: Different formulations of ethosomes using lecithin, cholesterol and ethanol were prepared using different doses of Mangifera indica herbal leaf extracts. Carbopol 940 was used to prepare ethosomal gel. The entrapment efficiency of ethosomes was 65.1%-96.54% and the average vesicle size was 920nm. Three formulations (different doses) were selected based on entrapment efficiency and drug release and used for further incorporation into gel formulations. Prepared gels were then evaluated for physicochemical characteristics and drug content. Results: The pH of the gel formulations was found to be in the range of 5.4-6.2. viscosities of gels were ranging between 2250- 2399 centipoises. The drug content of gels ranged between 74.67-82.31% Conclusion: The present study revealed ethosomal gel as an efficient drug delivery system for herbal extract. Keywords: Ethanol, Lecithin, transdermal, Mangifera indica.