PHARMACOLOGICAL EVALUATION OF NEWER BENZOTRIAZOLE DERIVATIVES FOR ANTIPSYCHOTIC AND ANTI INFLAMMATORY ACTIVITIES

The present study was undertaken to evaluate the antipsychotic potential of benzotriazole derivatives in experimental animal models. Male Wistar rats (180-220 g) and albino mice (25-30 g) were used for the study. The antipsychotic effect of the benzotriazole derivatives was evaluated on continuous avoidance response apparatus and anti-inflammatory activity by Carrageenan induced paw edema method. The benzotriazole derivative produced significant dose dependent potentiation in continuous avoidance response in rats, significantly decreased the time taken by the rat to press the lever and regulates the edema related to the time when compared with the carrageenan given alone. The results suggest that benzotriazole derivatives possess antipsychotic activity and anti-inflammatory activity. Further neurochemical investigation can explore the mechanism of action of the newer benzotriazole derivatives with respect to anti-dopaminergic functions and help to establish them as an antipsychotic agent. Key words: Benzotriazole derivatives, anti-psychotic activity, anti-inflammatory activity, continuous avoidance response.