Bacteriological profile and its antibiotic susceptibility in patients with Urinary Tract Infection at Tertiary Care Hospital, Valsad, Gujarat

Introduction: Urinary tract infection is one of the most common bacterial infections seen in humans and major cause of morbidity. The causative agents for urinary tract infection vary from place to place and they also vary in their sensitivity and resistance pattern with the widespread availability of antimicrobial drugs. UTI is difficult to treat because of appearance of pathogens with increasing resistant pattern to antimicrobial drugs. Aim: This study is carried out to know the bacteriological profile and its antibiotics sensitivity pattern in patients with UTI at tertiary care hospital, Valsad. Materials and Method: Total 771 mid-stream urine samples were collected from suspected UTI patients. They were tested for bacterial culture and all Culture positive samples were tested for antimicrobial susceptibility by Kirby- Bauer disc diffusion method. Results: Out of total 771 samples, isolates were detected in 302(39.16%) samples. Incidence of infection was more common in females (55%) as compared to males (45%). Escherichia coli (36.75%) was the most common pathogens followed by Kleseilla spp. (18.21%), Gram positive organisms (16.22%), Pseudomonas spp. (12.25%) and Candida spp.(8.60%). Isolated pathogenic organism shows high resistance to commonly use antibiotic and sensitive to higher generation of fluroquinolones and carbapenemase. Conclusion: In this study, females were mostly affected and most common organisms were E.coli and Klebseilla. The commonly isolated pathogens have been changing and increasing resistance pattern is observed due to indiscriminate use of antibiotics and alerting us to update effective empirical treatment regularly.