Role of 2D echo in neonates with perinatal asphyxia and its correlation with cardiac troponin T levels and creatine kinase MB

Objectives: To evaluate myocardial function in neonates with perinatal asphyxia by 2D Echo and cardiac Troponin T levels and creatine kinase MB. Methods: 30 term babies with perinatal asphyxia were selected as cases. They were evaluated within 48 hours of birth using clinical echocardiography and cardiac enzymes i.e. Troponin -T and CK-MB levels. Results: Incidence of cardiac dysfunction in neonates were reported and correlated with cardiac Troponin T levels and creatine phosphokinase MB- levels. In this study overall, 30% cases were reported with cardiogenic shock and cardiovascular dysfunction. 20% cases had clinical evidence of murmur. 16.6% cases had cardiac failure and 3.3% cases were asymptomatic. Cardiac enzymes were significantly increased in babies with perinatal asphyxia. Cardiac Troponin t levels ranges from 0.15- >=0.3ng/ml. CPK-MB levels ranged from 200±110 IU/L in this study. Tricuspid regurgitation seen in 6.7% cases. RV hypokinesia (67% cases) >LV hypokinesia (33.3%) cases. Incidence of cardiac changes and mortality increases with increasing levels of Troponin T.Mortality was seen in 2 out of 30 cases. The mean Troponin -T level in cases with cardiac dysfunction was 0.3ng/ml as compared to without cardiac dysfunction (