INFLUENCE OF FLUCONAZOLE ON HYPOGLYCAEMIC ACTIVITY OF ORAL ANTIDIABETIC AGENTS IN HEALTHY RATS

The influence of fluconazole pre-treatment on the hypoglycaemic effect of pioglitazone (10 mg/kg, p.o) and rosiglitazone (720 μg/kg, p.o) was studied. This study was conducted on healthy albino rats of either sex, randomly distributed into four different groups. They were pretreated with fluconazole (18 mg/kg and 36 mg/kg, p.o for 7 days) in 2% w/V gum acacia suspension for seven days. On eighth day, rosiglitazone and pioglitazone were administered to respective groups one hour after fluconazole treatment. Blood samples were collected by retro orbital plexus under light ether anesthesia at time intervals of 0, 1, 2, 4, 8, 12, 18 and 24 hours. The hypoglycaemic activity of thiazolidinediones was studied and it indicated that fluconazole pretreatment has enhanced the hypoglycaemic effect of rosiglitazone and pioglitazone significantly. Hence, it is suggested that during the concomitant usage of fluconazole and thiazolidinediones, therapeutic drug monitoring is essential and may also require readjusting the dose and frequency of administration of thiazolidinediones.