EFFECT OF WHEAT BRAN CONSUMPTION ON SERUM LIPID PROFILE OF HYPERCHOLESTEROLEMIA PATIENTS RESIDENCE IN HOLLY MAKAH

Background: Hypercholesterolemia is a metabolic disorder resembling a major risk factor for cardiovascular diseases. It is associated with hypertension, atherosclerosis, diabetes and hypertriglyceredemias. Therefore, it is not surprising that hypercholesterolemia subjects have more susceptibility to sudden death. Dietary intervention is the first-line approach. Increasing dietary fiber has been discussed recommended as a safe and practical approach for cholesterol reduction (Truswell, 2000). Objective: This study was performed to quantify the cholesterol-lowering effect of wheat bran as dietary fibers in hypercholesteremia patients. Design: a study design was conducted and used to test the effect of wheat bran consumption on serum lipid profile. Independent variables were the type and the amount of insoluble fiber, initial cholesterol concentration, and other important study characteristics. Results: Insoluble fiber was associated with slight but significant decreases in serum total cholesterol, low density lipoprotein (LDL), triglycerides and total serum cholesterol, (149.67±39.62 to121.89±44.38), (157.89±49.19 to156.67±68.13) and (214.11±43.052 to 193.89 ±42.30) respectively. LDL/HDL and total cholesterol/HDL ratios had been decreased significantly after wheat bran consumption (3.76±1.35 to 3.17±1.62) and (4.85±2.05 to 4.71 ±1.78) respectively. Serum levels of high density lipoprotein (HDL) were elevated in respondents following wheat bran consumption for one month ( 42.45±12.47 to 43.22±13.69). Conclusions: wheat bran as dietary fibers can decrease serum levels of total and LDL cholesterol. The positive effect of wheat bran consumption on lipid profile was little within the practical range of intake. Increasing insoluble fiber as dietary therapy can lower blood cholesterol level in patients suffering from hypercholesterolemia.